Contemporary research is increasingly data-centric and the rise of genomics revolutionized our approach and use of genetic resources. However, genomics developed relatively independently from the international instruments on the conservation of biological diversity, in particular the Access and Benefit Sharing (ABS) framework. The legal and political status of Digital Sequence Information (DSI) derived from genetic resources emerged recently as a contentious point in the various ABS instruments dealing with genetic resources. In view of the multiple parallel and uncoordinated debates that occurred in various forums dealing with plants, animals, terrestrial, microbial, marine and agricultural biodiversity, we propose here to take a step back in the discussion. We argue that DSI should be considered as an overarching issue to be addressed through a coordinated and inclusive Multi-stakeholder Committee that would assess its position and role within the existing ABS regime complex. This Multi-stakeholder Committee on the Governance of Digital Sequence Information, that may run under the auspices of the United Nations, will be dedicated to mitigate global governance issues associated with the digitization of genetic resources. In this paper, we sketch this body as a transversal and inclusive tool to facilitate long-term coherence in all ABS policy forums.